The INCLUDE Project Update

The new INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) project was launched by NIH in June 2018 to address critical research needs for people with DS (INCLUDE ProjectExternal Web Site Policy). We are pleased to share four recently released research opportunities for this new NIH research initiative. These Funding Opportunity Announcements (FOAs) are for 2019 funding and interested researchers should take special notice of the deadlines.

Here are links to the FOAs:

·         INCLUDE Clinical Trial Readiness (R21 Clinical Trial Not Allowed) Exploratory/Developmental Research Grant: Web Site Policy

·         Clinical Trials Development for Co-Occurring Conditions in Individuals with DS (R61/R33 Clinical Trials Required) Exploratory/Developmental Phased Innovation Award: Web Site Policy

·         Transformative Research Award for the INCLUDE Project (R01 Clinical Trial Not Allowed): Web Site Policy

·         Notice of Availability of Competitive Supplements/Revisions for the INCLUDE Project: Web Site Policy

·         Notice of Availability of Administrative Supplements/Revisions for the INCLUDE Project:  Web Site Policy


Awards from these new FOAs will help researchers address the three components of the INCLUDE project: (1) basic science studies aimed at improving the health of people with DS, (2) development of a research cohort for DS across the lifespan, and (3) ultimately, clinical trials for people with DS to improve their health and quality of life. 

Led by Melissa Parisi, Chief of NICHD’s Intellectual and Developmental Disabilities Branch, and Anna Mazzucco from the NIH Director’s office, a wide range of NIH Institutes and Centers are participating, making this truly a trans-NIH project.  We hope that families will be inspired to participate in research studies to move this major project forward!”